23rd Entry - Revisiting Quercetin as antidote to allergic response provoked by SARSCoV2 protein spike.

Revisiting Quercetin as antidote to allergic response provoked by SARSCoV2 protein.

This new insight posited by Nephrologist turned Genomicist @dwmoskowitz https://twitter.com/dwmoskowitz

In his own words from his @Twitter feeds -  https://twitter.com/dwmoskowitz/status/1358119705857449984

The spike protein of #SARSCoV2 is likely a basic secretagogue like the viral nucleocapsid protein. It triggers the Mas-related GPR X2 receptor on mast cells.

#Quercetin blocks the MRGPRX2 receptor and should be given with any vaccine.
https://www.scivisionpub.com/pdfs/quercetin-for-covid19-1196.pdf
Ultimately & basically, to protect from #COVID19 use at the minimum Quercetin & Zinc, also use Quercetin around the time of vaccinations as it can ward off dangerous side effects like anaphylactic shock to the viral spike protein as per @dwmoskowitz's advice.

Here is @dwmoskowitz https://twitter.com/dwmoskowitz online in pdf format:

https://www.scivisionpub.com/pdfs/quercetin-for-covid19-1196.pdf

The meat of the article - 

Quercetin was chosen because it is a high affinity (micromolar) inhibitor of the MRGPRX2 receptor [2].
MRGPRX2 is a recently described receptor located uniquely on the mast cell [3-5].
Mast cells are present in the lung and gut.
The MRGPRX2 receptor is promiscuous. It is activated by basic secretagogues [6], molecules that combine a strong positive charge with a hydrophobic portion.
Viral nucleocapsid proteins contain a strongly positive charge to bind the negatively charged phosphate backbone of the viral nucleic acid, while a hydrophobic segment of amino acids attaches to the viral membrane [7].
Specifically, COVID19 nucleocapsid contains an unusually basic region at amino acid #369-KKDKKKK-#375. SARS-1 contains the same segment at amino acids #370-376.
MRGPRX2 can activate the high affinity IgE receptor, Fc-epsilonRI, in the absence of pre-formed IgE. IgE signaling in the absence of IgE ensues, with mast cell degranulation and anaphylaxis.
The over 200 bioactive molecules released by the mast cell could easily account for the pathology seen in COVID19. Quercetin, the most common plant flavonoid, is inexpensive and readily available, present in onions, capers, tea, cilantro, apples, etc. It makes flowers yellow.
This patient was doing poorly but responded dramatically to quercetin. In the absence of any treatment for COVID19, Quercetin should certainly be considered.
It may even serve as prophylaxis.
In addition, Quercetin should be considered for additional viruses whose nucleocapsid proteins are basic secretagogues that could activate the mast cell MRGPRX2 receptor, such as Ebola and dengue, etc.
From the public health point of view, Quercetin is ideal.
It is safe: the average diet already consists of quercetin 10-15 mg/day, and large doses are well tolerated [10]. It may be the yellow lining in the COVID19 pandemic.

Important discovery - #Quercetin is a mast cell stabilizer. It blocks host's overly exuberant response. #Quercetin blocks #cytokinestorm, it doesn't matter which viral variant causes it. There's no way #SARSCoV2 can develop resistance to it. It allows for natural inoculation.

#Acutes Quercetin 500 mg twice a day of quercetin is good starting dose for most adults. If heavy (>200 lb) or severely ill, e.g. short of breath, start at 1 g twice a day. The key is double the dose every day symptoms persist, up to 3 g twice a day. As advised by @dwmoskowitz

An important note: no food, herb can contain enough #Quercetin in therapeutic dosage to help against #COVID19, the minimum required amount for prevention per day is 500mg, no choice but to supplement, average diets will never reach such high amounts.

For prevention, MD Dr Zev Zelenko from direct experience with patients advises the following -

    Quercetin 500 mg once a day

    Elemental Zinc 25 mg once a day

    Vitamin C 1,000 mg once a day.

All the above advice are congruent & in line with the antiviral protocol I put together for myself & family & those who care to stay alive & well - https://thenabsters.blogspot.com/2020/12/15th-entry-extra-covid19-anti-viral.html

...

As the half life of Quercetin is rather short, I suggest instead of 500 mg once a day as Dr. Zev Zelenko advises to rather take 500 mg twice a day, or to keep the lesser dosage he advises 250 mg twice a day.

The problem of course is to find 250 mg Quercetin dosage.

 

Also

@gglinskii

clearly states, protocol collated from several empirical positive reports goes far beyond #COVID19 mitigation. It's a baseline health-maintenance strategic approach to support T cell immunity, maintain healthy blood vessels & functionally adequate endothelial linings.

This antiviral immunotherapy protocol based solely on orthomolecular medicine compounds -

Maintenance doses I take & advise are:

Quercetin - 1 gm per day (divide in 2 doses every 12 hours).

Z

inc - 25 mg to 50 mg elemental Zinc per day.

Bromelain - 500 mg per day

Vitamin D3 - 6,000 UI per day (with K2)

Copper - 1,000 mcg per day

Vitamin C - 2 gm per day.

In acutes (like in the middle of the infection)

Quercetin - 2 gm to 6 gm per day (divided in two doses every 12 hours).

Zinc - 50 mg

to 75 mg elemental Zinc per day.

Bromelain - 500 mg to 1 g per day.

Vitamin D3 - 10,000 UI per day (with K2).

Copper - 1,000 mcg per day.

Vitamin C - 4 gm per day.

K2 dosage advice in entry 15 of this blog.

Usually the infection should clear within a few days to a week, doses of Vitamin C can be increased as needed but then above 4 gm per day get a multi mineral supplement including magnesium, calcium & potassium as minerals with high doses of Vitamin C get chelated by the body, also it is reported that Quercetin reduces amounts of Vitamin C.

The above were my own trial & error dealing with my own SARSCoV2 Covid-19 infection, follow up by a good naturopath/nutritionist/herbalist is recommended.

Note -

Orthomolecular medicine which was pioneered by the late double Nobel Prize recipient Linus Pauling advocates the use of natural extracted supplements in much higher doses than in addressing nutritional deficiency, it has now become mainstream in alternative natural therapies.